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1️⃣ Zonulin – The “Gatekeeper” Protein

Zonulin is a protein that controls the tight junctions in your gut lining

—think of it as the body’s way of deciding how “open” or “closed” your gut barrier should be.

High zonulin levels = increased gut permeability (leaky gut)

Low zonulin levels = stronger gut barrier

If zonulin is too high, your gut lining is overly open, allowing toxins and

undigested food particles to leak into your bloodstream — potentially triggering inflammation,

food reactions, and autoimmune issues.

Common Triggers of High Zonulin:

✅ Gluten

✅ Dysbiosis (gut imbalances)

✅ Chronic stress

✅ Environmental toxins

2️⃣ Occludin – Structural Integrity of Your Gut Lining

Occludin is another key protein that helps maintain tight junctions in the gut barrier.

When occludin is elevated, it signals damage to the gut lining

—essentially, your intestinal wall isn’t as strong as it should be.

This often happens due to:

✅ Chronic inflammation

✅ Toxin exposure (heavy metals, mold, pesticides, etc.)

✅ Infections that weaken the gut barrier

If occludin levels are high, a practitioner will likely focus on reducing inflammation,

healing the gut lining, and restoring gut microbiome balance.

3️⃣ Candida – The Overgrowth Culprit

Candida is a type of yeast that naturally exists in your gut—but when it overgrows,

it can damage your gut lining and contribute to leaky gut.

Signs of Candida Overgrowth:

✅ Bloating and gas

✅ Sugar cravings

✅ Brain fog and fatigue

✅ Skin issues like acne or rashes

✅ Recurring yeast infections

High Candida markers in the KBMO Gut Barrier Test indicate that your gut may need rebalancing

—typically through diet changes, probiotics, and antifungal support.

4️⃣ Lipopolysaccharides (LPS) – The Inflammatory Toxin

LPS are toxic molecules found on the outer membrane of certain gut bacteria.

If they leak into the bloodstream, they trigger massive inflammation and immune responses.

Signs of LPS Leakage (Endotoxemia):

✅ Chronic fatigue

✅ Joint pain and stiffness

✅ Brain fog and mood issues

✅ Digestive problems

✅ Autoimmune flare-ups

High LPS levels often indicate gut dysbiosis, bacterial overgrowth, or a severely leaky gut. Reducing LPS typically involves rebuilding gut microbiome diversity, strengthening gut lining integrity, and controlling inflammation.